Mitochondrial dysfunction and HIF1α stabilization in inflammation
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction and HIF1alpha stabilization in inflammation.
Activation of murine-derived J774.A1 macrophages with interferon gamma and lipopolysaccharide leads to a progressive mitochondrial defect characterized by inhibition of oxygen consumption and a decrease in the generation of ATP by oxidative phosphorylation. These changes are dependent on the generation of nitric oxide (NO) by an inducible NO synthase that becomes a significant consumer of oxyge...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.115949